ea0044oc1.2 | Early Career Oral Communications | SFEBES2016
Verma Manu
, Kipari Tiina
, Man Tak Yung
, Forster Thorsten
, Homer Natalie
, Seckl Jonathan
, Holmes Megan
, Chapman Karen
Chronically elevated glucocorticoid (GC) level impairs cognition. In rodents, elevated plasma GC levels, prior to an inflammatory challenge, potentiates neuroinflammation that is abolished by GR but not MR antagonism. 11β-hydroxysteroid dehydrogenase type-1 (11β-HSD1) increases intracellular GC levels by regenerating active GCs from inert forms. Inhibition/deficiency of 11β-HSD1 is protective against age-related cognitive decline presumably by lifelong reduced b...